کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6806332 | 1433572 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment
ترجمه فارسی عنوان
آتروفی هیپوکامپ و کورتیک در اختلالات شناختی خفیف آمیلوئید منفی: مقایسه با اختلالات شناختی خفیف آمیلوئید مثبت
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Although patients with amnestic mild cognitive impairment (aMCI) are at higher risk of developing Alzheimer's disease (AD), their pathologies could be heterogeneous. We aimed to evaluate structural changes in amyloid-negative and amyloid-positive aMCI patients. Forty-eight aMCI patients who underwent Pittsburgh compound B (PiB) positron emission tomography were recruited. They were classified as PiB (â) aMCI (NÂ = 16) and PiB (+) (NÂ = 32). Hippocampal shape and regional cortical thickness were compared with 41 subjects with normal cognition (NC). Relative to NC, PiB(â) aMCI exhibited hippocampal deformity in the right cornu ammonis 1, whereas PiB(+) aMCI exhibited hippocampal deformity in bilateral subiculum and cornu ammonis 1 subregions. Relative to NC, PiB(â) aMCI showed cortical thinning in the left medial prefrontal and right anterior temporal regions, whereas PiB(+) aMCI exhibited cortical thinning in bilateral medial temporal regions, temporoparietal junctions and precuneus, and prefrontal cortices. Our findings suggest that structural changes in PiB(â) aMCI might be due to several possible pathologic changes, whereas structural changes in PiB(+) aMCI reflect AD-like structural changes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 35, Issue 2, February 2014, Pages 291-300
Journal: Neurobiology of Aging - Volume 35, Issue 2, February 2014, Pages 291-300
نویسندگان
Byoung Seok Ye, Sang Won Seo, Chi Hun Kim, Seun Jeon, Geon Ha Kim, Young Noh, Hanna Cho, Cindy W. Yoon, Hee Jin Kim, Eun Young Jang, Jeongmin Lee, Jung-Hyun Kim, Juhee Chin, Jong Min Lee, Jeong-Hun Kim, Joon-kyung Seong, Chang-Hun Kim, Yearn Seong Choe,