کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6807263 | 1433581 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in subcortical structures in early- versus late-onset Alzheimer's disease
ترجمه فارسی عنوان
تغییرات در ساختارهای زیرکوریته در بیماری آلزایمر در اوایل و در اوایل شروع
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کلمات کلیدی
Subcortical structureEarly onset - آغاز زودرسAmygdala - آمیگدال، بادامهLongitudinal study - بررسی طولیAlzheimer's disease - بیماری آلزایمرThalamus - تالاموسOnset age - سن شروعbasal ganglia - عقدههای قاعدهایcaudate nucleus - هسته دم دارHippocampus - هیپوکامپ Putamen - پوسته، پوتامنGlobus pallidus - گوی رنگ پریده، گلوبوس پالیدوس
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Patients with early-onset Alzheimer's disease (EOAD) are reported to be different from those with late-onset Alzheimer's disease (LOAD) in terms of neuropsychological and neuroimaging findings. In this study, we aimed to compare the longitudinal volume changes of 6 subcortical structures (the amygdala, hippocampus, thalamus, putamen, globus pallidus, and caudate nucleus) between patients with EOAD and LOAD for 3 years. We prospectively recruited 36 patients with probable Alzheimer's disease (14 EOAD, 22 LOAD) and 14 normal control subjects. We analyzed the volume of subcortical structures using an automatic surface-based method. At baseline, there were no differences in the volumes of subcortical structures between patients with EOAD and LOAD. However, over 3 years of longitudinal follow-up, patients with EOAD showed more rapid volumetric decline in the caudate, putamen, and thalamus than patients with LOAD, which is consistent with neuropsychological results. Our findings suggested that the cognitive reserve theory might be applicable to explain different decline rates of the volumes of the basal ganglia and thalamus according to onset age.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 34, Issue 7, July 2013, Pages 1740-1747
Journal: Neurobiology of Aging - Volume 34, Issue 7, July 2013, Pages 1740-1747
نویسندگان
Hanna Cho, Sang Won Seo, Jeong-Hun Kim, Changsoo Kim, Byoung Seok Ye, Geon Ha Kim, Young Noh, Hee Jin Kim, Cindy W. Yoon, Joon-Kyung Seong, Chang-Hun Kim, Sue J. Kang, Juhee Chin, Sung Tae Kim, Kyung-Han Lee, Duk L. Na,