کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6807359 | 1433582 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aging-like circadian disturbances in folate-deficient mice
ترجمه فارسی عنوان
اختلالات شبح مانند سالمندان در موش های ضعیف فولات
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کلمات کلیدی
ریتم شبانه روزی، اسید فولیک، هموسیستئین، سالخورده، تنظیم مجدد رویایی، جت-تاخیر،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
The elderly population shows various circadian disturbances, including dampened amplitude of rhythmicity and decreased responsiveness to light. The common poor folate status in the elderly might account for these aging-related circadian disturbances. To test this hypothesis, we investigated whether folate deficiency in mice affects circadian oscillations of the master clock in the suprachiasmatic nuclei, and the shifting responses to light. Mice fed a diet without folate for 6 weeks displayed markedly reduced (4.5-fold) erythrocyte folate concentration and increased (2.3-fold) homocysteinemia compared with control mice. Folate deficiency decreased the circadian amplitude of vasopressin and the clock protein PERIOD 2 (PER2) in the master clock, slowed the rate of re-entrainment of behavioral rhythms after delayed light-dark cycle and reduced light-induced phase-delays, without detectable morphologic changes in the retina, such as the number of melanopsinergic ganglion cells, that might have impaired photodetection. In conclusion, folate deficiency and consecutive hyperhomocysteinemia led to dampened PER2 and vasopressin oscillations in the master clock and reduced responsiveness to photic resetting, which constitute hallmarks of aging effects on circadian rhythmicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 34, Issue 6, June 2013, Pages 1589-1598
Journal: Neurobiology of Aging - Volume 34, Issue 6, June 2013, Pages 1589-1598
نویسندگان
Etienne Challet, Stéphanie Dumont, Madah K.M. Mehdi, Caroline Allemann, Tiffanie Bousser, Sylviane Gourmelen, Dominique Sage-Ciocca, David Hicks, Paul Pévet, Bruno Claustrat,