کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6809461 | 1433597 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2A (5-HT2A) receptors. To establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-HT2A receptor and the serotonin transporter binding, the latter as a measure of serotonergic projections and neurons. Twelve patients with AD (average Mini Mental State Examination [MMSE]: 24) and 11 healthy age-matched subjects underwent positron emission tomography (PET) scanning with [18F]altanserin and [11C]N,N-Dimethyl-2-(2-amino-4-cyanopheylthio)benzylamine ([11C]DASB). Overall [18F]altanserin binding was markedly reduced in AD by 28%-39% (p = 0.02), whereas the reductions in [11C]DASB binding were less prominent and mostly insignificant, except for a marked reduction of 33% in mesial temporal cortex (p = .0005). No change in [11C]DASB binding was found in the midbrain. We conclude that the prominent reduction in neocortical 5-HT2A receptor binding in early AD is not caused by a primary loss of serotonergic neurons or their projections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 33, Issue 3, March 2012, Pages 479-487
Journal: Neurobiology of Aging - Volume 33, Issue 3, March 2012, Pages 479-487
نویسندگان
Lisbeth Marner, Vibe G. Frokjaer, Jan Kalbitzer, Szabolcs Lehel, Karine Madsen, William F.C. Baaré, Gitte M. Knudsen, Steen G. Hasselbalch,