کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6809666 | 1433597 | 2012 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons
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کلمات کلیدی
httNeuroinflammation - التهاب عصبیinterleukin-6 - اینترلوکین ۶Huntington's disease - بیماری هانتینگتونprotein aggregation - تجمع پروتئینNeurodegeneration - تولید نوروژنیکNeurotoxicity - سمیت عصبیSlice culture - فرهنگ لغزشComplement - متممmicrogliosis - میکروگلویوزیسMicroglia - میکروگلیاهاNeurite - نوریتHuntingtin - هانتینگتن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
In Huntington's disease (HD), mutated huntingtin (mhtt) causes striatal neurodegeneration which is paralleled by elevated microglia cell numbers. In vitro corticostriatal slice and primary neuronal culture models, in which neuronal expression of mhtt fragments drives HD-like neurotoxicity, were employed to examine wild type microglia during both the initiation and progression of neuronal pathology. As neuronal pathology progressed, microglia initially localized in the vicinity of neurons expressing mhtt fragments increased in number, demonstrated morphological evidence of activation, and expressed the proliferation marker, Ki67. These microglia were positioned along irregular neurites, but did not localize with mhtt inclusions nor exacerbate mhtt fragment-induced neurotoxicity. Prior to neuronal pathology, microglia upregulated ionized calcium binding adaptor molecule 1 (Iba1), signaling a functional shift. With neurodegeneration, interleukin-6 and complement component 1q were increased. The results suggest a stimulatory, proliferative signal for microglia present at the onset of mhtt fragment-induced neurodegeneration. Thus, microglia effect a localized inflammatory response to neuronal mhtt expression that may serve to direct microglial removal of dysfunctional neurites or aberrant synapses, as is required for reparative actions in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 33, Issue 3, March 2012, Pages 621.e17-621.e33
Journal: Neurobiology of Aging - Volume 33, Issue 3, March 2012, Pages 621.e17-621.e33
نویسندگان
Andrew D. Kraft, Linda S. Kaltenbach, Donald C. Lo, G. Jean Harry,