کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6817287 | 546705 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transcranial magnetic stimulation potentiates glutamatergic neurotransmission in depressed adolescents
ترجمه فارسی عنوان
تحریک مغناطیسی ترانس مغناطیسی باعث انتقال نوروتروژنی گلوتاماترگیک در نوجوانان افسرده می شود
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کلمات کلیدی
ACCFDRICC1H-MRSGLNCDRS-RFAST - سریعintraclass correlation coefficient - ضریب همبستگی داخل کلاسیProton magnetic resonance spectroscopy - طیف سنجی رزونانس مغناطیسی پروتونanterior cingulate cortex - قشر سینگولیت قدامی، کورتکس سینگولیت قدامیCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیfalse discovery rate - میزان کشف کاذبGlu - گلوglutamate - گلوتاماتglutamine - گلوتامین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Abnormalities in glutamate neurotransmission may have a role in the pathophysiology of adolescent depression. The present pilot study examined changes in cortical glutamine/glutamate ratios in depressed adolescents receiving high-frequency repetitive transcranial magnetic stimulation. Ten adolescents with treatment-refractory major depressive disorder received up to 30 sessions of 10-Hz repetitive transcranial magnetic stimulation at 120% motor threshold with 3000 pulses per session applied to the left dorsolateral prefrontal cortex. Baseline, posttreatment, and 6-month follow-up proton magnetic resonance spectroscopy scans of the anterior cingulate cortex and left dorsolateral prefrontal cortex were collected at 3Â T with 8-cm3 voxels. Glutamate metabolites were quantified with 2 distinct proton magnetic resonance spectroscopy sequences in each brain region. After repetitive transcranial magnetic stimulation and at 6 months of follow-up, glutamine/glutamate ratios increased in the anterior cingulate cortex and left dorsolateral prefrontal cortex with both measurements. The increase in the glutamine/glutamate ratio reached statistical significance with the TE-optimized PRESS sequence in the anterior cingulate cortex. Glutamine/glutamate ratios increased in conjunction with depressive symptom improvement. This reached statistical significance with the TE-optimized PRESS sequence in the left dorsolateral prefrontal cortex. High-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex may modulate glutamate neurochemistry in depressed adolescents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 247, 30 January 2016, Pages 25-33
Journal: Psychiatry Research: Neuroimaging - Volume 247, 30 January 2016, Pages 25-33
نویسندگان
Paul E. Croarkin, Paul A. Nakonezny, Christopher A. Wall, Lauren L. Murphy, Shirlene M. Sampson, Mark A. Frye, John D. Port,