کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6817762 | 1433954 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Estrogens and their receptors in the medial amygdala rapidly facilitate social recognition in female mice
ترجمه فارسی عنوان
استروژن و گیرنده های آن در آمیگدال میانی به سرعت تشخیص اجتماعی را در موش های زنانه تسهیل می کنند
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Estrogens have been shown to rapidly (within 1â¯h) affect learning and memory processes, including social recognition. Both systemic and hippocampal administration of 17β-estradiol facilitate social recognition in female mice within 40â¯min of administration. These effects were likely mediated by estrogen receptor (ER) α and the G-protein coupled estrogen receptor (GPER), as administration of the respective receptor agonists (PPT and G-1) also facilitated social recognition on a rapid time scale. The medial amygdala has been shown to be necessary for social recognition and long-term manipulations in rats have implicated medial amygdalar ERα. As such, our objective was to investigate whether estrogens and different ERs within the medial amygdala play a role in the rapid facilitation of social recognition in female mice. 17β-estradiol, G-1, PPT, or ERβ agonist DPN was infused directly into the medial amygdala of ovariectomized female mice. Mice were then tested in a social recognition paradigm, which was completed within 40â¯min, thus allowing the assessment of rapid effects of treatments. 17β-estradiol (10, 25, 50, 100â¯nM), PPT (300â¯nM), DPN (150â¯nM), and G-1 (50â¯nM) each rapidly facilitated social recognition. Therefore, estrogens in the medial amygdala rapidly facilitate social recognition in female mice, and the three main estrogen receptors: ERα, ERβ, and the GPER all are involved in these effects. This research adds to a network of brain regions, including the medial amygdala and the dorsal hippocampus, that are involved in mediating the rapid estrogenic facilitation of social recognition in female mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 89, March 2018, Pages 30-38
Journal: Psychoneuroendocrinology - Volume 89, March 2018, Pages 30-38
نویسندگان
Jennifer M. Lymer, Paul A.S. Sheppard, Talya Kuun, Andrea Blackman, Nilay Jani, Sahnon Mahbub, Elena Choleris,