کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6818582 547001 2015 41 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ethinyl estradiol and levonorgestrel alter cognition and anxiety in rats concurrent with a decrease in tyrosine hydroxylase expression in the locus coeruleus and brain-derived neurotrophic factor expression in the hippocampus
ترجمه فارسی عنوان
اتینیل استرادیول و لوونورژسترل تغییر شناخت و اضطراب در موش های صحرایی همزمان با کاهش بیان هورمون های تیروزین هیدروکسیلاز در لوکوس کورولوس و بیان فاکتور نوروترفیک مغز در هیپوکمپ
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
In the United States, more than ten million women use contraceptive hormones. Ethinyl estradiol and levonorgestrel have been mainstay contraceptive hormones for the last four decades. Surprisingly, there is scant information regarding their action on the central nervous system and behavior. Intact female rats received three weeks of subcutaneous ethinyl estradiol (10 or 30 μg/rat/day), levonorgestrel (20 or 60 μg/rat/day), a combination of both (10/20 μg/rat/day and 30/60 μg/rat/day), or vehicle. Subsequently, the rats were tested in three versions of the novel object recognition test to assess learning and memory, and a battery of tests for anxiety-like behavior. Serum estradiol and ovarian weights were measured. All treatment groups exhibited low endogenous 17β-estradiol levels at the time of testing. Dose-dependent effects of drug treatment manifested in both cognitive and anxiety tests. All low dose drugs decreased anxiety-like behavior and impaired performance on novel object recognition. In contrast, the high dose ethinyl estradiol increased anxiety-like behavior and improved performance in cognitive testing. In the cell molecular analyses, low doses of all drugs induced a decrease in tyrosine hydroxylase mRNA and protein in the locus coeruleus. At the same time, low doses of ethinyl estradiol and ethinyl estradiol/levonorgestrel increased galanin protein in this structure. Consistent with the findings above, the low dose treatments of ethinyl estradiol and combination ethinyl estradiol/levonorgestrel reduced brain-derived neurotrophic factor mRNA in the hippocampus. These effects of ethinyl estradiol 10 μg alone and in combination with levonorgestrel 20 μg suggest a diminution of norepinephrine input into the hippocampus resulting in a decline in learning and memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 62, December 2015, Pages 265-278
نویسندگان
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