کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6819097 547401 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In a rat model of panic, corticotropin responses to dorsal periaqueductal gray stimulation depend on physical exertion
ترجمه فارسی عنوان
در یک مدل موش هراس، پاسخ کورتیکوتروپین به تحریک خاکستری پشتی پر پشت، به اعمال جسمی بستگی دارد
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Panic disorder patients are exquisitely and specifically sensitive to hypercapnia. The demonstration that carbon dioxide provokes panic in fear-unresponsive amygdala-calcified Urbach-Wiethe patients emphasizes that panic is not fear nor does it require the activation of the amygdala. This is consonant with increasing evidence suggesting that panic is mediated caudally at midbrain's dorsal periaqueductal gray matter (DPAG). Another startling feature of the apparently spontaneous clinical panic is the counterintuitive lack of increments in corticotropin, cortisol and prolactin, generally considered 'stress hormones'. Here we show that the stress hormones are not changed during DPAG-evoked panic when escape is prevented by stimulating the rat in a small compartment. Neither did the corticotropin increase when physical exertion was statistically adjusted to the same degree as non-stimulated controls, as measured by lactate plasma levels. Conversely, neuroendocrine responses to foot-shocks were independent from muscular effort. Data are consonant with DPAG mediation of panic attacks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 53, March 2015, Pages 136-147
نویسندگان
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