کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6819097 | 547401 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In a rat model of panic, corticotropin responses to dorsal periaqueductal gray stimulation depend on physical exertion
ترجمه فارسی عنوان
در یک مدل موش هراس، پاسخ کورتیکوتروپین به تحریک خاکستری پشتی پر پشت، به اعمال جسمی بستگی دارد
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
حمله وحشت ماده خاکستری پرایاکوداکت، فشار، کورتیکوتروپین، کورتیکواسترون، پرولاکتین،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Panic disorder patients are exquisitely and specifically sensitive to hypercapnia. The demonstration that carbon dioxide provokes panic in fear-unresponsive amygdala-calcified Urbach-Wiethe patients emphasizes that panic is not fear nor does it require the activation of the amygdala. This is consonant with increasing evidence suggesting that panic is mediated caudally at midbrain's dorsal periaqueductal gray matter (DPAG). Another startling feature of the apparently spontaneous clinical panic is the counterintuitive lack of increments in corticotropin, cortisol and prolactin, generally considered 'stress hormones'. Here we show that the stress hormones are not changed during DPAG-evoked panic when escape is prevented by stimulating the rat in a small compartment. Neither did the corticotropin increase when physical exertion was statistically adjusted to the same degree as non-stimulated controls, as measured by lactate plasma levels. Conversely, neuroendocrine responses to foot-shocks were independent from muscular effort. Data are consonant with DPAG mediation of panic attacks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 53, March 2015, Pages 136-147
Journal: Psychoneuroendocrinology - Volume 53, March 2015, Pages 136-147
نویسندگان
Rubia de Souza Armini, Cristian Setúbal Bernabé, Caroline Azevedo Rosa, Carlos Antônio Siller, Fagna Giacomin Schimitel, Sérgio Tufik, Donald Franklin Klein, Luiz Carlos Schenberg,