Three-Dimensional Local Energy-Based Shape Histogram (3D-LESH): A Novel Feature Extraction Technique

The contribution of this article is manifold. First, we formulate a novel 3D-LESH feature extraction technique for 3D medical images to analyse volumetric images. Further, the proposed 3D-LESH algorithmis, for the first time, applied to medical MRI images. The final contribution is the design of an intelligent clinical decision support system (CDSS) as a multi-stage approach, combining novel 3D-LESH feature extraction with machine learning classifiers, to detect cancer from breast MRI scans. The proposed system applies contrast-limited adaptive histogram equalisation (CLAHE) to the MRI images before extracting 3D-LESH features. Furthermore, a selected subset of these features is fed into a machine-learning classifier, namely, a support vector machine (SVM), an extreme learning machine (ELM) or an echo state network (ESN) classifier, to detect abnormalities and distinguish between different stages of abnormality. We demonstrate the performance of the proposed technique by its application to benchmark breast cancer MRI images. The results indicate high-performance accuracy of the proposed system (98%±0.0050, with an area under a receiver operating charactertistic curve value of 0.9900 ± 0.0050) with multiple classifiers. When compared with the state-of-the-art wavelet-based feature extraction technique, statistical analysis provides conclusive evidence of the significance of our proposed 3D-LESH algorithm.