Continuous production of single enantiomers at high yields by coupling single column chromatography, racemization, and nanofiltration

A process combining single-column chromatography, racemization and solvent removal by membrane filtration to produce single enantiomers at high yields is proposed and investigated. Shortcut design methods are developed for a basic design using only a single chromatogram as input without the need for dynamic process simulation. A detailed process model is used to elucidate the role of relevant parameters and process dynamics. Experimental investigation of the process in fully coupled operation demonstrate the capability of the concept to produce single enantiomers at high yield and purity, as well as the applicability of the proposed design methods.

► A proposed reactor-separator-recycle process improves significantly yield and performance of enantiomer productions.
► Single column chromatography is an efficient and flexible alternative to more complex process configurations.
► Simple shortcut methods facilitate fast design and performance evaluation.
► For the first time an experimental implementation of such concept in fully coupled operation is reported.