Complex between Human RNase HI and the phosphonate-DNA/RNA duplex: Molecular dynamics study

- 200-1000 ns MD simulations produced using GPU and the ACEMD software package.
- Biologically active 3pc5 phosphonate oligonucleotide binds to RNase H.
- Biologically inactive 3cp5 phosphonate oligonucleotide dissociates from RNase H.
- Glu512 completes the catalytic tetrad of Thermus thermophilus Argonaute.