کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6893525 | 1445564 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry
ترجمه فارسی عنوان
تحولات اخیر در فرآیند بلوری: به سوی صنعت داروسازی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
بلورسازی، مهندسی کریستال، پلی مورفیسم، طراحی و کنترل فرایند فرآوری، توزیع اندازه کریستال،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
علوم کامپیوتر (عمومی)
چکیده انگلیسی
Crystallization is one of the oldest separation and purification unit operations, and has recently contributed to significant improvements in producing higher-value products with specific properties and in building efficient manufacturing processes. In this paper, we review recent developments in crystal engineering and crystallization process design and control in the pharmaceutical industry. We systematically summarize recent methods for understanding and developing new types of crystals such as co-crystals, polymorphs, and solvates, and include several milestones such as the launch of the first co-crystal drug, Entresto (Novartis), and the continuous manufacture of Orkambi (Vertex). Conventional batch and continuous processes, which are becoming increasingly mature, are being coupled with various control strategies and the recently developed crystallizers are thus adapting to the needs of the pharmaceutical industry. The development of crystallization process design and control has led to the appearance of several new and innovative crystallizer geometries for continuous operation and improved performance. This paper also reviews major recent progress in the area of process analytical technology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Engineering - Volume 3, Issue 3, June 2017, Pages 343-353
Journal: Engineering - Volume 3, Issue 3, June 2017, Pages 343-353
نویسندگان
Zhenguo Gao, Sohrab Rohani, Junbo Gong, Jingkang Wang,