Co-precipitation of mefenamic acid−polyvinylpyrrolidone K30 composites using Gas Anti-Solvent

• Production of MEF–PVP composites was performed by GAS.
• An increase in drug-to-polymer ratio resulted in a higher % drug content.
• An increase in temperature or drug-to-polymer ratio resulted in larger particle size.
• MEF–PVP composites could dissolve 7 times faster than the unprocessed MEF.

In this study, composites of mefenamic acid (MEF) and polyvinylpyrrolidone K30 (PVP K30, MW ∼ 40,000) were synthesized by applying the Gas Anti-Solvent (GAS) technique. It was found that an increase in drug-to-polymer ratio resulted in a higher % drug content. However, temperature and solution concentration had no significant effect on the % drug content when the amount of polymer in the solution was lower than or equal to that of the drug. The dissolution rate of the MEF−PVP composites was found to be 7 times and 3 times greater than those of the unprocessed MEF and physical mixture, respectively.

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