کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
690428 1460411 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation, antibacterial activity and pH-responsive release behavior of silver sulfadiazine loaded bacterial cellulose for wound dressing applications
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تکنولوژی و شیمی فرآیندی
پیش نمایش صفحه اول مقاله
Preparation, antibacterial activity and pH-responsive release behavior of silver sulfadiazine loaded bacterial cellulose for wound dressing applications
چکیده انگلیسی


• Bacterial cellulose (BC)-AgSD composites were successfully prepared.
• BC-AgSD composites have pH-sensitive controlled release behaviors.
• BC-AgSD composites exhibited excellent antibacterial activities.
• BC-AgSD composites showed good biocompatibility.
• The prepared composites have great potential application in wound dressing applications.

Bacterial cellulose (BC) has been extensively explored as some of the most promising biomaterials for biomedical applications. However, BC does not have intrinsically antibacterial property. In the present study, antibacterial BC-silver sulfadiazine (AgSD) composites were prepared by a simple blend method since AgSD is a topical antibacterial agents used as a topical cream on burns. The prepared composites were characterized by several techniques including SEM, FTIR, XRD and TG. These results indicate AgSD was successfully impregnated into BC matrix. The releases of Ag+ and SD− ions from BC-AgSD composites at different pH values were studied, which showed pH-sensitive controlled release behaviors. The antibacterial performances of BC-AgSD composites were evaluated with Staphylococcus aureus and Candida albicans. Moreover, the cytotoxicity of BC-AgSD composites was performed on HEK293 cells. The present work demonstrates a facile way to prepare BC-AgSD composites with excellent antibacterial activities and good biocompatibility, which can be used as potential wound dressings.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Taiwan Institute of Chemical Engineers - Volume 63, June 2016, Pages 404–410
نویسندگان
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