Micellization phenomena of amphiphilic drug and TX-100 mixtures: Fluorescence, UV-visible and 1H NMR study

• Nagg, Ksv and dielectric constant of mixed systems have been evaluated.
• The I1/I3 values (>1) suggest more polar environment around pyrene in the mixed micelle.
• 1H NMR data suggested that AMT and TX-100 interacts through hydrophobic interaction.
• The results have relevancy in model drug delivery.

Herein, we have accounted the interaction of an antidepressant drug amitriptyline hydrochloride (AMT) with nonionic surfactant (TX-100) in aqueous solutions using different spectroscopic techniques. The difference in structure of the AMT and TX-100 surfactant also play a crucial role for the aggregational phenomena of the amphiphiles mixed systems. Critical micelle concentration (cmc) of different mixtures was evaluated from the I1/I3versus total amphiphile concentration plots. cmc value of pure drug and TX-100 as well as their mixtures in different ratio were also computed by dye solubilization method using UV–visible spectrophotometer. The different physicochemical parameters, such as micellar mole fraction (X1Rub), activity coefficients (f1m, f2m), micropolarity, micelle aggregation number (Nagg), Stern–Volmer binding constants (Ksv) and dielectric constant (Dexp) have been evaluated for all solution mixture. Micelle aggregation numbers (Nagg) suggest that the involvement of TX-100 in the micelles was more than that of the AMT. Nuclear magnetic resonance (1H NMR) data of solution mixtures suggested that AMT and TX-100 interacts through hydrophobic interaction.

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