Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: A multi-drug system for theranostic in rheumatoid arthritis

- Pegylated PLGA nanospheres with MTX and Au NPs were synthesized.
- Addition of Au NPs greatly improves the MTX release under acidic conditions.
- The novel theranostic nanospheres are taken up by monocytes and macrophages.
- MTX/Au NPs co-loaded nanospheres showed significant anti-inflammatory activity.