Modification of oral absorption of oxyresveratrol using lipid based nanoparticles

- The SLN and NLC containing hydrophilic oxyresveratrol were prepared by a high shear homogenization technique.
- Physicochemical characterizations and in vitro drug release were investigated.
- The in vivo pharmacokinetic profiles implied enterohepatic recycling of oxyresveratrol in the rats.
- The SLN and NLC enhanced the oral bioavailability of oxyresveratrol compared to unformulated drug.