Rod shaped nanocrystals exhibit superior in vitro dissolution and in vivo bioavailability over spherical like nanocrystals: A case study of lovastatin

Sonoprecipitation was used to prepare lovastatin (LOV) rod shaped nanocrystals (LOV-RNs), and wet media milling was applied for the preparation of spherical like nanocrystals (LOV-SNs). LOV-RNs exhibit superior in vitro dissolution and in vivo bioavailability over LOV-SNs.