Improved DNA microarray detection sensitivity through immobilization of preformed in solution streptavidin/biotinylated oligonucleotide conjugates

- Immobilization approach based on biotinylated oligo/streptavidin conjugates.
- Enhanced oligonucleotides immobilization efficiency and detection sensitivity.
- Improved hybridization kinetics and discrimination ability of mutations.
- Microarray for detection of seven most common BRCA1 gene mutations in 40 min.