Chitosan-hyaluronic acid/VEGF loaded fibrin nanoparticles composite sponges for enhancing angiogenesis in wounds

- Chitosan-HA/VEGF loaded sponge was developed and characterized.
- Developed sponge showed controlled release of VEGF.
- Developed sponge showed better swelling, porosity and degradation.
- Developed sponge is cyto-compatible toward HDF cells.
- Enhanced proliferation and tube formation are shown in HUVECs.