Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration

- Modeling various functional groups (CH3, NH2, OH and COOH) to examine surface chemistry regulating endothelial cell migration.
- Exploring the expressions and distributions of signal molecules in integrin-FAs-FAK-Rho GTPase signaling pathway.
- Determining the whole pathway from integrins to Rho GTPases participation in surface-induced cell migration.
- Building a diagram to describe the difference and potential mechanism of surface mediating cell migration.
- Providing a broad overview of surface chemistry regulating endothelial cell migration and establishes associations among surface chemistry, cell adhesion/migration behavior and associated signaling events.