Dual drug delivery of 5-fluorouracil (5-FU) and methotrexate (MTX) through random copolymeric nanomicelles of PLGA and polyethylenimine demonstrating enhanced cell uptake and cytotoxicity

- Random copolymer synthesis of PLGA and BPEI for MTX conjugation by DCC/NHS chemistry.
- Preparation of nanomicelles of 5-FU-PBP-MTX with ultimate desired properties.
- Superior 5-FU entrapment in PBP-MTX nanomicelles.
- High amount of cellular uptake and cytotoxicity exhibited by the nanomicelles in vitro.