Collagen-functionalised titanium surfaces for biological sealing of dental implants: Effect of immobilisation process on fibroblasts response

- Smooth or nanorough titanium surfaces are obtained by O2 plasma or acid etching.
- Silanisation enhances collagen stability on titanium as compared to physisorption.
- Fibroblast activation related genes are overexpressed on collagen-coated surfaces.
- Collagen-mediated fibroblast activation is higher on plasma vs acid etched surfaces.