کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6982847 1454282 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeted delivery of doxorubicin into tumor cells via MMP-sensitive PEG hydrogel-coated magnetic iron oxide nanoparticles (MIONPs)
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Targeted delivery of doxorubicin into tumor cells via MMP-sensitive PEG hydrogel-coated magnetic iron oxide nanoparticles (MIONPs)
چکیده انگلیسی

- MMP-sensitive and RGDS functional PEG hydrogel coating around MIONPs is developed.
- Multifunctional coating induces targeted drug release into cancer cells.
- Cancer cell viability was compromised within 2 h via targeted drug release.
- Drug loaded nanoparticles have minimum cytotoxic damage to healthy cells.
- The approach will be useful for cancer cell diagnosis and targeted drug delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 122, 1 October 2014, Pages 674-683
نویسندگان
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