Polymeric micelles for acyclovir drug delivery

- Acyclovir was used directly to initiate polymerization of ɛ-caprolactone.
- ACV-tagged micelles were self-assembled by conjugation with hydrophilic poly(ethylene glycol) or chitosan.
- ACV-tagged polymeric micelles are non-toxic.
- ACV-tagged micelles are advantageous in terms of eliminating drug-loading steps, enhancing drug-carrying capacity, and decreasing production cost.