Interactions of serum with polyelectrolyte-stabilized liposomes: Cryo-TEM studies

- We examine the morphological changes of liposomes exposed to the serum environment.
- Bare liposomes are disintegrated by serum as a result of high osmotic shock.
- Polymer coating prevents the destruction of liposome vehicles by serum.
- Polymer structure is crucial to the interactions of coated liposomes with serum.
- Lipid membranes become more fluid after the addition of serum.