A Langmuir monolayer study of the action of phospholipase A2 on model phospholipid and mixed phospholipid-GM1 ganglioside membranes

- Phospholipases A2 (PLA2) are dependent on the properties of the lipid system.
- The rate of the PLA2 catalyzed hydrolysis of DLPC decreases in the presence of GM1.
- The decrease of the reaction rate may be due to H-bonding of the lipid polar heads.