Reduction-degradable PEG-b-PAA-b-PEG triblock copolymer micelles incorporated with MTX for cancer chemotherapy

- Reduction-degradable copolymers were synthesized in a simple one-step process.
- Copolymers effectively encapsulated anti-cancer drugs to form spherical micelles.
- Drugs were reduction-triggered released under the reductive condition.
- MTX-encapsulated micelles showed significant cytotoxicity to tumor cells.