Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials

- Surface grafting with poly(N-vinyl-2-pyrrolidinone) significantly increased drug binding capacity.
- Sustained drug release provided antifungal and biofilm-controlling effects for weeks to months.
- The released drugs can be repeatedly recharged back onto the denture materials to further extend antifungal duration.
- In recharging, drugs can be changed or switched.
- Drug release can be stopped by “washing out” the absorbed drug.