Flurbiprofen PLGA-PEG nanospheres: Role of hydroxy-β-cyclodextrin on ex vivo human skin permeation and in vivo topical anti-inflammatory efficacy

- PLGA-PEG NSs with or without HPβCD were prepared for FB topical delivery.
- NSs showed a 9-fold improvement in FB skin retention over the control solution.
- HPβCD NSs exhibited the strongest inhibition of TPA-induced edema on mouse ears.
- NSs showed no irritation on the rabbit skin.
- NSs could be good candidates for FB topical delivery with minimal side effects.