کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7005715 | 1455134 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A continuous multi-stage mixed-suspension mixed-product-removal crystallization system with fines dissolution
ترجمه فارسی عنوان
یک سیستم کریستالیزه شدن مخلوط با محصول مخلوط چند مرحله ای با یک حلقه نقرهای
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
تصفیه و جداسازی
چکیده انگلیسی
This work demonstrates how crystal particle size is affected by the addition of fines dissolution in a mixed suspension mixed product removal (MSMPR) cascade system. The cooling crystallization of paracetamol in water was used as a case study. Two MSMPR cascade configurations were evaluated: (i) nucleation-growth (NG), and (ii) nucleation-dissolution-growth (NDG). Simulation results demonstrate that adding a dissolution step in the MSMPR cascade configuration increases the average product crystal size. Larger crystals and a narrower distribution were obtained due to the removal of fine crystals through the continuous process. However, a small decrease in the achievable yield was observed. Experimental results also showed a similar effect on the final mean size and CSD. The results demonstrate that a dissolution stage can be optimized to increase the final crystal size and CSD by varying the dissolution temperature to optimize the CSD with minimum effect on the achievable yield.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Research and Design - Volume 135, July 2018, Pages 112-120
Journal: Chemical Engineering Research and Design - Volume 135, July 2018, Pages 112-120
نویسندگان
David Acevedo, Daniel J. Jarmer, Christopher L. Burcham, Christopher S. Polster, Zoltan K. Nagy,