Monitoring of cocrystallization of ethenzamide-saccharin: Insight into kinetic process by in situ Raman spectroscopy

- In situ Raman spectroscopy was applied to explore the mechanism.
- The solution-mediated phase transformation is controlled by the nucleation rate.
- Johnson-Mehl-Avrami equation was used to calculate the kinetics parameter.
- The effect of different operating factors was studied to understand the process.