Preparation and statistical optimization of Losartan Potassium loaded nanoparticles using Box Behnken factorial design: Microreactor precipitation

- Losartan Potassium (LP) loaded nanoparticles were prepared by microreactor technology.
- Box-Behnken statistical design was used to study the effects of independent variables on selected dependent variables.
- Release kinetics and comparison of optimized LP formulations with marketed formulation were studied.