کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7019896 1455944 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Separation of D, L-amino acids using ligand exchange membranes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تصفیه و جداسازی
پیش نمایش صفحه اول مقاله
Separation of D, L-amino acids using ligand exchange membranes
چکیده انگلیسی
Chiral ligand exchange membranes were synthesized for potential use in racemic filtration applicable to the pharmaceutical industry. Regenerated cellulose membranes with 1 kDa molecular weight cutoff (MWCO) were grafted with chiral L-proline-copper complexes through an intermediate epoxy-silane surface functionalization reaction performed for various times (0, 1.5, 3, 6, 12 and 24 h). The resulting membranes were evaluated in single component diffusion experiments with D or L-Phenylalanine (Phe), which showed much higher permeability for D-Phe compared with L-Phe. The membranes were then evaluated under pressure-driven, single enantiomer filtration and all grafted membranes exhibited predicted enantiomeric excess, with the 6 h epoxy-silane modified membrane yielding 100% enantiomeric excess (EE) over the largest throughput. An equimolar racemic mixture of D,L-Phe was subsequently used to challenge the optimum 6 h epoxy-silane modified membrane, and a two-tiered breakthrough curve was obtained. As predicted by the single enantiomer filtration results, the membrane was shown to completely fractionate the enantiomers at Peclet numbers of ~ 400. The high Peclet number during filtration combined with complete enantiomer fractionation is very intriguing as a competitive technology to chiral chromatography. Simply exposing the membrane surface to the epoxy-silane, L-proline, and copper solution presents a facile and scalable method for membrane surface modification.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Membrane Science - Volume 555, 1 June 2018, Pages 30-37
نویسندگان
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