کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7021279 1456007 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A simple but efficient zwitterionization method towards cellulose membrane with superior antifouling property and biocompatibility
ترجمه فارسی عنوان
یک روش ساده اما کارآمد برای غربالگری سلولز با ویژگی های ضد انعقادی برتر و سازگاری زیستی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تصفیه و جداسازی
چکیده انگلیسی
Cellulose membrane has been widely used for bioseparation and blood purification but suffers from fouling issue and insufficient biocompatibility. Surface grafting of zwitterions onto membrane surface can effectively alleviate this issue. Current grafting methods are mostly based on free radical polymerizations and have limitations of multi-step process, the requirement of inert atmosphere and inevitable flux decline. Herein we put forward a simple method for cellulose membrane (CM) zwitterionization. The modification was carried out via a one-step method based on the alkoxysilane condensation reaction using three silane coupling agents including (3-carboxypropylbetaine-propyl)-trimethoxysilane (CPPT), (3-sulfopropylbetaine-propyl)-trimethoxysilane (SPPT), and (3-sulfobutylbetaine-propyl)-trimethoxysilane (SBPT). Membrane surfaces were characterized by ATR-FTIR, XPS, SEM, water contact angle (WCA) and streaming potential. Membrane mechanical performance, pore size and its distributions were measured. The antifouling property, hemocompatibility and cytocompatibility of the membranes were evaluated by protein adsorption, platelet adhesion, cell attachment and MTT assay experiments. The results show that sulfobetaines and carboxybetaines were successfully grafted on the CM surface. The obtained zwitterions-grafted membranes show excellent resistance to protein adhesion, platelet adhesion and cell attachment. More importantly, the biocompatibility of the CM membrane was retained.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Membrane Science - Volume 492, 15 October 2015, Pages 547-558
نویسندگان
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