Calorimetric manifestation of IgA monoclonal immunoglobulins in multiple myeloma sera

The present study explores the manifestation of IgA monoclonal immunoglobulins in the thermograms of multiple myeloma sera. We show that the electrophoretic mobility of IgA paraproteins is related to altered intermolecular interactions, plausibly the formation of IgA oligomers and/or albumin-IgA complexes. We demonstrate that high IgA levels exhibit specific calorimetric features that discriminate IgA MM from other MM subtypes.