کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7069 533 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria
چکیده انگلیسی

We previously reported that nanoceria can slow retinal degeneration in the tubby mouse for two weeks by multiple systemic injections. However, the long-term protection of retinal structure and function by directly deliver of nanoceria to the eye had not been explored. In this study, 172 ng of nanoceria in 1 μl saline (1 mm) were intravitreally injected into tubby P7 pups and assays were performed at P28, P49, P80 and P120. The expression of antioxidant associated genes and photoreceptor-specific genes was significantly up regulated, the mislocalization of rod and cone opsins was decreased, and retinal structure and function were protected. These findings demonstrate that nanoceria can function as catalytic antioxidants in vivo and may be broad spectrum therapeutic agents for multiple types of ocular diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 33, Issue 34, December 2012, Pages 8771–8781
نویسندگان
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