Drug Interaction Between Propofol and Remifentanil in Individualised Drug Delivery Systems

Optimal and safe control of drug delivery systems with continuous infusion protocol is of key importance to avoid over-dosing or under-dosing of the patient. Advanced model based control techniques are able to predict and regulate the amount of drugs given to the patient but they rely heavily on patient model. This paper discusses and investigates the effects of synergistic drug interaction between Propofol (hypnotic) and Remifentanil (opioid) and its requirements on the robustness and stability of the closed loop system.