Modelling of BIS-Index Dynamics for Total Intravenous Anesthesia Simulation in Matlab-Simulink⁎

The data were recorded by an Orchestra Base Primea infusion workstation and a Lidco monitor. The data parser and the model developed in the Matlab-Simulink environment provide a basis for further refining the dynamic model and for development and validation of closed-loop control approaches for DoA. The presented model allows conducting simulations and tests of various scenarios of propofol administration within the Matlab-Simulink environment with the goal of a deeper insight into the mechanisms of DoA dynamics. This will lead to better administration methods that will benefit the patient, relieve the workload and allow the anesthesiologist to focus on the critical aspects of the procedure.