کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7140315 | 1462026 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lamb wave-based blood coagulation test
ترجمه فارسی عنوان
تست انعقاد خون مبتنی بر موج بره
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کلمات کلیدی
موج شانه، انعقاد خون، محلول کلسیم، زمان پروترومبین،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Blood coagulation tests are a critical part in diagnosis of patients with bleeding disorders and cardiovascular diseases. However, most conventional blood coagulation tests require large and expensive instruments and skilled personnel. Here, we present a simple and low-cost approach to evaluate blood coagulation using Lamb wave-based device. To assess coagulation, we monitored the acoustic streaming of 5â¯Î¼m fluorescent particles suspended in citrated plasma. Using a Lamb wave, citrated blood plasma and coagulation reagents can be mixed in a few seconds and the viscosity of the droplet increases due to blood coagulation. Then, the acoustic streaming of particles eventually stops, at which the “coagulation time” is defined. As a preliminary test, coagulation time was reduced with increasing calcium concentration from 0 to 25â¯mM. Prothrombin time results from the Lamb wave-based device were validated by comparing with those of commercial instruments with the correlation coefficient (R2) as 0.9432. Using the Lamb wave for blood coagulation test, the temperature can be controlled as 37â¯Â°C simultaneously by modulating experimental conditions. Our device enables lithography-free, simple and low-cost measurement of blood coagulation, which can be applied to clinical settings and developing countries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 263, 15 June 2018, Pages 190-195
Journal: Sensors and Actuators B: Chemical - Volume 263, 15 June 2018, Pages 190-195
نویسندگان
Jeonghun Nam, Hyunjoo Choi, Jae Young Kim, Woongsik Jang, Chae Seung Lim,