Whole-cell amperometric biosensor for screening of cytochrome P450 inhibitors

To the best of our knowledge, the system developed enables for the first time rapid and cheap cytochrome P450 inhibitors detection by a disposable whole-cell electrochemical chip, combined with the advantages of a whole-cell system, without neither enzyme purification nor NADPH addition. Furthermore, the system developed also provides capability of performing aniline detection e.g. for environmental monitoring, by means of electrochemical biosensing.