کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7147448 1462100 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pneumatically controlled multi-level microchannel for separation and extraction of microparticles
ترجمه فارسی عنوان
میکرو کانال چند سطحی تحت کنترل پنوماتیک برای جداسازی و استخراج میکروکاست
کلمات کلیدی
میکرو سازه، فوتولیتوگرافی در مقیاس خاکستری، میکروکانالهای چند سطح، جداسازی، استخراج، ذرات کوچک،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Most microfluidic devices are fabricated by using standard photolithography technology so that they are typically limited to a single, uniform microchannel depth. In this work, we employ a polydimethylsiloxane (PDMS) gray-scale photomask (PGSP) developed in our previous work for fabricating multi-level microchannels (MLMs) that hold a high potential for enhancing the separation performance and efficiency of microparticles. Since the PGSP provides a series of multiple, uniform and precise filter gaps in a microchannel, we describe an MLM-integrated microfluidic device that not only filters but also accumulates microparticles by size such as polystyrene beads and yeast cells. In addition, we integrate a pneumatic pressure controller that manually manipulates the filter gaps to enable sequential extraction of the separated, accumulated microparticles from the device for additional post-analysis. Since the PGSP-based soft-lithography technology provides a simple but powerful fabrication method for MLMs, we believe that both the fabrication method and the separation and extraction device can be widely used for micro total analysis systems that benefit from MLMs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 190, January 2014, Pages 86-92
نویسندگان
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