کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7149662 | 1462117 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quartz crystal microbalance monitoring of intervention of doxorubicin-loaded core-shell magnetic silica nanospheres on human breast cancer cells (MCF-7)
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
We prepare core-shell type magnetic silica nanospheres (Fe3O4@SiO2) as drug carriers for cellular delivery of the widely used anticancer drug doxorubicin (DOX). The cytotoxicity of doxorubicin-loaded magnetic silica composite (DOX-Fe3O4@SiO2) on human breast cancer cells (MCF-7) are studied by dynamic quartz crystal microbalance (QCM) monitoring, cyclic voltammetry (CV) characterization, 3-(4,5-dimethylthizaol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and optical microscopic inspections, and agreeable conclusions are drawn from various methods. We find that the DOX-Fe3O4@SiO2 are able to induce cell death in a dose-dependent way and exhibit higher cytotoxicity under external magnetic field in comparison with the free DOX, suggesting the potential of the Fe3O4@SiO2 for targeting drug-delivery. The QCM sensor-based in situ/process monitoring in combination with ex situ/static analyses based on CV, MTT and optical microscopic inspections provides a reliable and informative experimental platform for investigating incubation of cells and interventions from exogenous substances.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 173, October 2012, Pages 433-440
Journal: Sensors and Actuators B: Chemical - Volume 173, October 2012, Pages 433-440
نویسندگان
Yaping Zhou, Yanzi Zeng, Siyu Huang, Qingji Xie, Yingchun Fu, Liang Tan, Ming Ma, Shouzhuo Yao,