کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7155264 | 1462615 | 2016 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Emergence of drug-resistance in HIV dynamics under distinct HAART regimes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی مکانیک
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چکیده انگلیسی
In this paper we propose a model for the dynamics of HIV epidemics under distinct HAART regimes, and study the emergence of drug-resistance. The model predicts HIV dynamics of untreated HIV patients for all stages of the infection. We compute the local and the global stability of the disease-free equilibrium of the model. We simulate the model for two distinct HIV patients, the rapid progressors and the long-term non-progressors. We study the effects of equal RTI and PI efficacies, as well as distinct drug efficacies, namely RTI-based and PI-based therapeutics. Treatment is initiated when the CD4+ T cells count is less than 350 cells mmâ3. The PI-based drugs seem to produce better outcomes, with respect to disease progression, than RTI-based regimes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Communications in Nonlinear Science and Numerical Simulation - Volume 30, Issues 1â3, January 2016, Pages 207-226
Journal: Communications in Nonlinear Science and Numerical Simulation - Volume 30, Issues 1â3, January 2016, Pages 207-226
نویسندگان
Ana R.M. Carvalho, Carla M.A. Pinto,