Contribution of fluid in bone extravascular matrix to strain-rate dependent stiffening of bone tissue - A poroelastic study

- Examined rate-dependent role of fluid in bone using a poroelastic micro-FE approach.
- Hydraulic stiffening depends highly on bone microstructure.
- Poroelastic rate-dependency in bone is more significant in cortical samples.
- Hydraulic stiffening in bone depends highly on loading and boundary conditions.
- Discussed suitable boundary conditions for in vivo mechanical characterization.