کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7208093 | 1469086 | 2016 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanical properties and failure analysis of visible light crosslinked alginate-based tissue sealants
ترجمه فارسی عنوان
خواص مکانیکی و تجزیه و تحلیل شکست نور مرئی بافتی بافت های بافت آلژینات
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کلمات کلیدی
پیوند نور نور قابل مشاهده، آلژینات، اکسیداسیون، لرزش فشار، سیلانت بافت
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
چکیده انگلیسی
Moderate to weak mechanical properties limit the use of naturally-derived tissue sealants for dynamic medical applications, e.g., sealing a lung leak. To overcome these limitations, we developed visible-light crosslinked alginate-based hydrogels, as either non-adhesive methacrylated alginate (Alg-MA) hydrogel controls, or oxidized Alg-MA (Alg-MA-Ox) tissue adhesive tissue sealants, which form covalent bonds with extracellular matrix (ECM) proteins. Our study investigated the potential for visible-light crosslinked Alg-MA-Ox hydrogels to serve as effective surgical tissue sealants for dynamic in vivo systems. The Alg-MA-Ox hydrogels were designed to be an injectable system, curable in situ. Burst pressure experiments were conducted on a custom-fabricated burst pressure device using constant air flow; burst pressure properties and adhesion characteristics correlated with the degrees of methacrylation and oxidation. In summary, visible light crosslinked Alg-MA-Ox hydrogel tissue sealants form effective seals over critically-sized defects, and maintain pressures up to 50Â mm Hg.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 59, June 2016, Pages 314-321
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 59, June 2016, Pages 314-321
نویسندگان
Patrick N. Charron, Spencer L. Fenn, Alex Poniz, Rachael A. Oldinski,