The essential role of inorganic substrate in the migration and osteoblastic differentiation of mesenchymal stem cells

- Collagen enhances MSC adhesion and proliferation, but inhibits OB differentiation.
- The inorganic matrix modulates the cytoskeleton organization and migration.
- A strong correlation between the MSC motility with the OB differentiation.
- Inorganic matrix activates of WNT pathway, stimulating OB differentiation.