Mechanically tissue-like elastomeric polymers and their potential as a vehicle to deliver functional cardiomyocytes

Non-linearly elastic biomaterials were successfully fabricated from a chemically cross-linked elastomeric poly(glycerol sebacate) and thermoplastic poly(lactic acid) using the core/shell electrospinning technique. The spun fibrous materials demonstrated J-shaped stress-strain curves, having mechanical properties being comparable to muscle tissue properties. The PGS/PLLA fibrous biomaterials possess excellent biocompatibility, capable of supporting human stem-cell-derived cardiomyocytes.238