کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7236329 1471092 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of the cross-linkers on the buckling of microtubules in cells
ترجمه فارسی عنوان
اثرات متقابل لینکرها بر خم شدن میکروتوبول ها در سلول ها
کلمات کلیدی
میکروتوبول ها، لرزش محلی محلی، پیوند پروتئینی، چگالی محلی لینکرها،
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
In cells, the protein cross-linkers lead to a distinct buckling behavior of microtubules (MTs) different from the buckling of individual MTs. This paper thus aims to examine this issue via the molecular structural mechanics (MSM) simulations. The transition of buckling responses was captured as the two-dimensional-linkers were replaced by the three-dimensional (3D) ones. Then, the effects of the radial orientation and the axial density of the 3D-linkers were examined, showing that more uniform distribution of the radial orientation leads to the higher critical load with 3D buckling modes, while the inhomogeneity of the axial density results in the localized buckling patterns. The results demonstrated the important role of the cross-linker in regulating MT stiffness, revealed the physics of the experimentally observed localized buckling and these results will pave the way to a new multi-component mechanics model for whole cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 72, 27 April 2018, Pages 167-172
نویسندگان
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